I get quite a bit of spam. Some of it may be from previous postings on Usenet, or public web pages, but some of it is from spammers just grabbing an Intel mass mail account and spamming the whole frikkin corporation.
One thing to remember: If it says "reply to blah blah to remove", don't do it. Some spam programs VERIFY thier email addresses by you doing this. When you think you are being removed, you are actually verifying a valid email address to spam.
Best tactic is to ignore them. If you get a bunch, contact your ISP (or IT department if at work). They can help track down the culprits and beat the shit out of them. Well, that's what I would like them to do. Unfortunatly, we have laws about that they tell me.